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Clinical Chemistry 32: 539-541, 1986;
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Clinical Chemistry, Vol 32, 539-541, Copyright © 1986 by American Association for Clinical Chemistry

Dietary citric acid enhances absorption of aluminum in antacids

P Slanina, W Frech, LG Ekstrom, L Loof, S Slorach and A Cedergren

Ten healthy men ingested, twice daily between meals, during each of the seven-day experimental periods: (a) citric acid (as lemon juice), (b) Al(OH)3, or (c) Al(OH)3 + citric acid. Whole blood sampled after each dietary period was analyzed electrothermally after digestion with nitric acid. Moderate, but significant, increases in mean Al concentrations as compared with pretreatment values [5 (SD 3) micrograms of Al per liter] were seen after ingestion of either citric acid or Al(OH)3: 9 (SD 4) and 12 (SD 3) micrograms/L, respectively. Ingestion of both Al(OH)3 and citric acid resulted in a more pronounced, highly significant (p less than 0.001) increase in Al concentrations, to 23 (SD 2) micrograms Al/L, probably owing to formation and absorption of Al-citrate complexes.


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Copyright © 1986 by the American Association for Clinical Chemistry.