Clinical Chemistry
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Clinical Chemistry 32: 552-555, 1986;
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Clinical Chemistry, Vol 32, 552-555, Copyright © 1986 by American Association for Clinical Chemistry

Fluorescence polarization immunoassay for theophylline modified for use with dried blood spots on filter paper

PK Li, JT Lee, KA Conboy and EF Ellis

We used dried blood spots successfully as alternative specimens for quantifying concentrations of theophylline in the circulation by a modified fluorescence polarization immunoassay (FPIA) with the Abbott TDx instrument. The method described is simple, rapid, and acceptably precise. More importantly, it can provide results comparable with those of the conventional serum assay. Results for 64 pairs of dried blood spots (y) and serum (x) specimens analyzed by the respective FPIA methods yielded the following regression parameters: y = 0.94x + 0.71, r = 0.988, and Sxy = 0.92. A major advantage of FPIA is that it requires only basic laboratory skills. When coupled with the use of dried blood spots, this system can be effective in remote theophylline monitoring, particularly suited for domiciliary care.


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S. Kaplan, K. Ozisik, J. A. Morgan, and R. Dogan
Measurement of Troponin T and I to detect cardioprotective effect of aminophylline during coronary artery bypass grafting
Interactive CardioVascular and Thoracic Surgery, September 1, 2003; 2(3): 310 - 315.
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Copyright © 1986 by the American Association for Clinical Chemistry.