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Clinical Chemistry, Vol 32, 671-673, Copyright © 1986 by American Association for Clinical Chemistry
J McElveen, MI Mackness, CM Colley, T Peard, S Warner and CH Walker
The activity of paraoxonase in serum was found to be bimodally distributed, both in a control group and in a group of patients who had suffered myocardial infarction. Activity in the myocardial infarct group was significantly lower than in the control group. Low paraoxonase activity in serum may provide an indication of susceptibility to the development of coronary heart disease.
The following articles in journals at HighWire Press have cited this article:
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  R. J. Richter, G. P. Jarvik, and C. E. Furlong Determination of Paraoxonase 1 Status Without the Use of Toxic Organophosphate Substrates Circ Cardiovasc Genet, December 1, 2008; 1(2): 147 - 152. [Full Text] [PDF]
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 M. Senti, M. Tomas, M. Fito, T. Weinbrenner, M.-I. Covas, J. Sala, R. Masia, and J. Marrugat Antioxidant Paraoxonase 1 Activity in the Metabolic Syndrome J. Clin. Endocrinol. Metab., November 1, 2003; 88(11): 5422 - 5426. [Abstract] [Full Text] [PDF]
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 B. Mackness, P. Durrington, P. McElduff, J. Yarnell, N. Azam, M. Watt, and M. Mackness Low Paraoxonase Activity Predicts Coronary Events in the Caerphilly Prospective Study Circulation, June 10, 2003; 107(22): 2775 - 2779. [Abstract] [Full Text] [PDF]
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 M. Rantala, M.-L. Silaste, A. Tuominen, J. Kaikkonen, J. T. Salonen, G. Alfthan, A. Aro, and Y. A. Kesaniemi Dietary Modifications and Gene Polymorphisms Alter Serum Paraoxonase Activity in Healthy Women J. Nutr., October 1, 2002; 132(10): 3012 - 3017. [Abstract] [Full Text] [PDF]
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 T. M. Forte, G. Subbanagounder, J. A. Berliner, P. J. Blanche, A. O. Clermont, Z. Jia, M. N. Oda, R. M. Krauss, and J. K. Bielicki Altered activities of anti-atherogenic enzymes LCAT, paraoxonase, and platelet-activating factor acetylhydrolase in atherosclerosis-susceptible mice J. Lipid Res., March 1, 2002; 43(3): 477 - 485. [Abstract] [Full Text] [PDF]
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 P. N. Durrington, B. Mackness, and M. I. Mackness Paraoxonase and Atherosclerosis Arterioscler Thromb Vasc Biol, April 1, 2001; 21(4): 473 - 480. [Abstract] [Full Text] [PDF]
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M. Senti, M. Tomas, J. Marrugat, R. Elosua, and f. t. REGICOR Investigators Paraoxonase1-192 Polymorphism Modulates the Nonfatal Myocardial Infarction Risk Associated With Decreased HDLs Arterioscler Thromb Vasc Biol, March 1, 2001; 21(3): 415 - 420. [Abstract] [Full Text] [PDF]
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B. J. Kudchodkar, A. G. Lacko, L. Dory, and T. V. Fungwe Dietary Fat Modulates Serum Paraoxonase 1 Activity in Rats J. Nutr., October 1, 2000; 130(10): 2427 - 2433. [Abstract] [Full Text]
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M. Tomas, M. Senti, F. Garcia-Faria, J. Vila, A. Torrents, M. Covas, and J. Marrugat Effect of Simvastatin Therapy on Paraoxonase Activity and Related Lipoproteins in Familial Hypercholesterolemic Patients Arterioscler Thromb Vasc Biol, September 1, 2000; 20(9): 2113 - 2119. [Abstract] [Full Text] [PDF]
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T. Kujiraoka, T. Oka, M. Ishihara, T. Egashira, T. Fujioka, E. Saito, S. Saito, N. E. Miller, and H. Hattori A sandwich enzyme-linked immunosorbent assay for human serum paraoxonase concentration J. Lipid Res., August 1, 2000; 41(8): 1358 - 1363. [Abstract] [Full Text]
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R. W. James, I. Leviev, and A. Righetti Smoking Is Associated With Reduced Serum Paraoxonase Activity and Concentration in Patients With Coronary Artery Disease Circulation, May 16, 2000; 101(19): 2252 - 2257. [Abstract] [Full Text] [PDF]
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R. C. Sorenson, C. L. Bisgaier, M. Aviram, C. Hsu, S. Billecke, and B. N. La Du Human Serum Paraoxonase/Arylesterase's Retained Hydrophobic N-Terminal Leader Sequence Associates With HDLs by Binding Phospholipids : Apolipoprotein A-I Stabilizes Activity Arterioscler Thromb Vasc Biol, September 1, 1999; 19(9): 2214 - 2225. [Abstract] [Full Text] [PDF]
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T. M. Forte, M. N. Oda, L. Knoff, B. Frei, J. Suh, J. A. K. Harmony, W. D. Stuart, E. M. Rubin, and D. S. Ng Targeted disruption of the murine lecithin:cholesterol acyltransferase gene is associated with reductions in plasma paraoxonase and platelet-activating factor acetylhydrolase activities but not in apolipoprotein J concentration J. Lipid Res., July 1, 1999; 40(7): 1276 - 1283. [Abstract] [Full Text]
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A. Ayub, M. I. Mackness, S. Arrol, B. Mackness, J. Patel, and P. N. Durrington Serum Paraoxonase After Myocardial Infarction Arterioscler Thromb Vasc Biol, February 1, 1999; 19(2): 330 - 335. [Abstract] [Full Text] [PDF]
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M. Aviram, S. Billecke, R. Sorenson, C. Bisgaier, R. Newton, M. Rosenblat, J. Erogul, C. Hsu, C. Dunlop, and B. La Du Paraoxonase Active Site Required for Protection Against LDL Oxidation Involves Its Free Sulfhydryl Group and Is Different From That Required for Its Arylesterase/Paraoxonase Activities : Selective Action of Human Paraoxonase Allozymes Q and R Arterioscler Thromb Vasc Biol, October 1, 1998; 18(10): 1617 - 1624. [Abstract] [Full Text] [PDF]
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T. Hayek, B. Fuhrman, J. Vaya, M. Rosenblat, P. Belinky, R. Coleman, A. Elis, and M. Aviram Reduced Progression of Atherosclerosis in Apolipoprotein E–Deficient Mice Following Consumption of Red Wine, or Its Polyphenols Quercetin or Catechin, Is Associated With Reduced Susceptibility of LDL to Oxidation and Aggregation Arterioscler Thromb Vasc Biol, November 1, 1997; 17(11): 2744 - 2752. [Abstract] [Full Text]
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M. Odawara, Y. Tachi, and K. Yamashita Paraoxonase Polymorphism (Gln192-Arg) Is Associated with Coronary Heart Disease in Japanese Noninsulin-Dependent Diabetes Mellitus J. Clin. Endocrinol. Metab., July 1, 1997; 82(7): 2257 - 2260. [Abstract] [Full Text] [PDF]
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D. K. Sanghera, N. Saha, C. E. Aston, and M. I. Kamboh Genetic Polymorphism of Paraoxonase and the Risk of Coronary Heart Disease Arterioscler Thromb Vasc Biol, June 1, 1997; 17(6): 1067 - 1073. [Abstract] [Full Text]
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C. A. Abbott, M. I. Mackness, S. Kumar, A. J. Boulton, and P. N. Durrington Serum Paraoxonase Activity, Concentration, and Phenotype Distribution in Diabetes Mellitus and Its Relationship to Serum Lipids and Lipoproteins Arterioscler Thromb Vasc Biol, November 1, 1995; 15(11): 1812 - 1818. [Abstract] [Full Text]
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R. A. Hegele, J. H. Brunt, and P. W. Connelly A Polymorphism of the Paraoxonase Gene Associated With Variation in Plasma Lipoproteins in a Genetic Isolate Arterioscler Thromb Vasc Biol, January 1, 1995; 15(1): 89 - 95. [Abstract] [Full Text]
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 E. Mutch, P. G. Blain, and F. M. Williams Interindividual Variations in Enzymes Controlling Organophosphate Toxicity in Man Human and Experimental Toxicology, January 1, 1992; 11(2): 109 - 116. [Abstract] [PDF]
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 B. J. Van Lenten, A. C. Wagner, M. Navab, and A. M. Fogelman Oxidized Phospholipids Induce Changes in Hepatic Paraoxonase and ApoJ but Not Monocyte Chemoattractant Protein-1 via Interleukin-6 J. Biol. Chem., January 12, 2001; 276(3): 1923 - 1929. [Abstract] [Full Text] [PDF]
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