Clinical Chemistry
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Clinical Chemistry 32: 691-693, 1986;
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Clinical Chemistry, Vol 32, 691-693, Copyright © 1986 by American Association for Clinical Chemistry

Immunoradiometric assay of thyrotropin as a "first-line" thyroid- function test in the routine laboratory

MR Hopton and JS Harrop

We compared the utility of a sensitive immunoradiometric assay for serum thyrotropin as a "first-line" thyroid-function test with a strategy based on first measuring total thyroxin in serum. The immunoradiometric assay appears to distinguish primary hypothyroidism and hyperthyroidism from euthyroidism in "new" patients. The role of this test in monitoring antithyroid treatment or thyroxin-replacement therapy is not yet established, there being particular difficulty in interpreting low thyrotropin concentrations in such patients. Nevertheless, because a normal thyrotropin concentration in most, if not all, situations signifies the euthyroid state, thyrotropin determination by immunoradiometric assay merits consideration as an initial test by laboratories performing thyroid-function tests.


The following articles in journals at HighWire Press have cited this article:


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 Arch Intern MedHome page
G. Sundbeck, R. Jagenburg, P.-M. Johansson, S. Eden, and G. Lindstedt
Clinical Significance of Low Serum Thyrotropin Concentration by Chemiluminometric Assay in 85-Year-Old Women and Men
Arch Intern Med, March 1, 1991; 151(3): 549 - 556.
[Abstract] [PDF]

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 Arch Intern MedHome page
C. T. Sawin, A. Geller, M. M. Kaplan, P. Bacharach, P. W. F. Wilson, and J. M. Hershman
Low Serum Thyrotropin (Thyroid-Stimulating Hormone) in Older Persons Without Hyperthyroidism
Arch Intern Med, January 1, 1991; 151(1): 165 - 168.
[Abstract] [PDF]


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Copyright © 1986 by the American Association for Clinical Chemistry.