Clinical Chemistry
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Clinical Chemistry 32: 703-705, 1986;
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Clinical Chemistry, Vol 32, 703-705, Copyright © 1986 by American Association for Clinical Chemistry

Four monoclonal immunoglobulins in a patient with chronic lymphocytic leukemia

A Tienhaara, K Irjala, A Rajamaki and K Pulkki

We report here the case of a 73-year-old woman with chronic lymphocytic leukemia. Two years after the diagnosis, electrophoresis of her serum showed two monoclonal fractions, but our modified immunofixation procedure revealed four monoclonal immunoglobulins in five fractions: two IgG lambda fractions, one IgG kappa fraction, one IgA kappa fraction, and one IgG kappa fraction. This is an exceptionally high number of monoclonal immunoglobulins in a single patient. In the course of her disease the patient did not show any clinical, radiological, or laboratory signs of multiple myeloma or macroglobulinemia. The different monoclonal immunoglobulins were considered to be one expression of her B-lymphocytic malignancy.




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Copyright © 1986 by the American Association for Clinical Chemistry.