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Clinical Chemistry 32: 983-986, 1986;
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Clinical Chemistry, Vol 32, 983-986, Copyright © 1986 by American Association for Clinical Chemistry

Rapid measurement of serum water to assess pseudohyponatremia

S Faye and RB Payne

Pseudohyponatremia is caused by an increased serum protein or lipid concentration producing a "space-occupying lesion" in serum water. Its presence and magnitude must be assessed in hyponatremic patients with, for example, paraproteinemia or hyperlipemic diabetic coma. In the absence of a direct-reading ion-selective electrode system, a method for measuring the water content of serum is required. We describe two rapid methods for measuring the diffusible water of serum: osmometry before and after dilution and chloride measurement before and after ultrafiltration. Either of these methods allows the true sodium status of a patient's serum to be determined.




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Copyright © 1986 by the American Association for Clinical Chemistry.