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Clinical Chemistry 32: 1368-1371, 1986;
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Clinical Chemistry, Vol 32, 1368-1371, Copyright © 1986 by American Association for Clinical Chemistry

Cyanocobalamin absorption in the elderly: results for healthy subjects and for subjects with low serum cobalamin concentration

H Nilsson-Ehle, R Jagenburg, S Landahl, G Lindstedt, B Swolin and J Westin

We examined the intestinal absorption of cyano[57Co]cobalamin from a non-protein-bound test dose given to 38 subjects from a population of elderly. The subjects were 76 years old and were apparently free from conditions known to affect cyanocobalamin absorption. Their gastric mucosal function was normal, as judged from determinations of serum gastrin and pepsinogen I. The urinary excretion of radioactivity during the first 24 h was 24(SD 7)%, range 8.6 to 45.2%, corresponding to a health-associated reference interval of 10 to 38%. The results indicate that cyanocobalamin absorption does not decline during normal aging. Duplicate studies were performed in another 20 subjects (70-81 years old) from the same population study; these subjects had a serum cobalamin concentration less than 130 pmol/L. The imprecision (CV) was 23%.


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I Aimone-Gastin, H Pierson, C Jeandel, J P Bronowicki, F Plenat, D Lambert, F Nabet-Belleville, and J L Gueant
Prospective evaluation of protein bound vitamin B12 (cobalamin) malabsorption in the elderly using trout flesh labelled in vivo with 57Co-cobalamin
Gut, October 1, 1997; 41(4): 475 - 479.
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Copyright © 1986 by the American Association for Clinical Chemistry.