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Clinical Chemistry 32: 1751-1755, 1986;
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Clinical Chemistry, Vol 32, 1751-1755, Copyright © 1986 by American Association for Clinical Chemistry

Radioimmunoassay for amatoxins by use of a rapid, 125I-tracer-based system

RY Andres, W Frei, K Gautschi and DJ Vonderschmitt

In this new radioimmunoassay system for determination of amatoxins in urine and plasma, a novel chemical approach is used for antigen and 125I-tracer production, based on a detoxified alpha-amanitin derivative (aldoamanitin). Total assay time, including data processing, is less than 100 min. The lowest detectable concentration is 1 microgram/L for urine, 0.1 microgram/L for plasma. In the clinically significant range, within-run CVs are less than 8%. This new 125I-based assay is a significant improvement over existing 3H technology in terms of speed, precision, and freedom from interference.




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Copyright © 1986 by the American Association for Clinical Chemistry.