Clinical Chemistry
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Clinical Chemistry 33: 153-158, 1987;
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Clinical Chemistry, Vol 33, 153-158, Copyright © 1987 by American Association for Clinical Chemistry

Electrochemical determination of hemoglobin, hematocrit, and hemolysis

RK Kobos, SD Abbott, HW Levin, H Kilkson, DR Peterson and JW Dickinson

Novel electrochemical methods have been developed for determination of total hemoglobin, hematocrit, and detection of hemolysis in whole blood. Hemoglobin is measured through its peroxidase activity, a fluoride ion-selective electrode being used to monitor the rate of fluoride ion production from the oxidation of an organofluorine compound. Results agree well with those obtained with the cyanmethemoglobin method (r = 0.970). Hematocrit is determined from the ratio of the sodium ion concentrations measured with an ion-selective electrode before and after lysis of the erythrocytes. Results by this and the microhematocrit method correlated well (r = 0.987). Hemolysis in a whole-blood sample is detected by using an oxygen electrode to measure the oxygen released when hemoglobin in plasma is oxidized.




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Copyright © 1987 by the American Association for Clinical Chemistry.