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Clinical Chemistry 33: 55-56, 1987;
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Clinical Chemistry, Vol 33, 55-56, Copyright © 1987 by American Association for Clinical Chemistry

The clinical usefulness of glycated hemoglobin in monitoring diabetes mellitus: a long-term study

S Lenzi, O Giampietro, G Giovannitti, T Sampietro, R Miccoli and R Navalesi

To assess the long-term clinical usefulness of measuring glycated hemoglobin (Hb A1), we carried out a two-year longitudinal study involving 234 diabetic patients (116 males, 118 females; 139 with type I diabetes mellitus, 95 with type II). Hb A1 values correlated significantly (p less than 0.001) with a score index based on plasma glucose in a specimen collected after overnight fasting, and urinary glucose, and ketones in a 24-h specimen. However, we found that one of every three well-controlled patients (both type I and II subjects) had high values for Hb A1. Among poorly controlled patients, only those with "brittle" diabetes had good values for Hb A1.




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Copyright © 1987 by the American Association for Clinical Chemistry.