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Clinical Chemistry 33: 57-61, 1987;
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Clinical Chemistry, Vol 33, 57-61, Copyright © 1987 by American Association for Clinical Chemistry

Intra-individual variation of some analytes in serum of patients with insulin-dependent diabetes mellitus

WG Holzel

Biological intra-individual variation in concentrations of 16 clinical biochemical analytes in serum was estimated for 27 patients with insulin-dependent diabetes mellitus (IDDM), and results were compared with those for apparently healthy individuals. In general, the variation was significantly higher in the patients. The ratio of the average intra-individual variation in IDDM patients to that in normal subjects exceeded 2.0 for Na+, K+, creatinine, and alpha-amylase; 1.50 to 2.0 for Cl-, total protein, albumin, cholesterol, and hemoglobin; and 1.2 to 1.5 for urea, uric acid, high-density-lipoprotein cholesterol, and aspartate aminotransferase. This increased variability in IDDM patients may be caused by variations in osmotic diuresis. Average intra-individual variations were greater for women than for men for Na+, total protein, albumin, and hemoglobin. Individual values showed a gaussian distribution for all analytes, including enzymes and triglycerides. No intra-individual variation was time dependent. For practical purposes, decision-making criteria in monitoring IDDM can be derived from the estimated biological component of intra-individual variation and the analytical variation established for each laboratory.


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 Clin. Chem.Home page
M. du Plessis, J. B. Ubbink, and W.J. H. Vermaak
Analytical Quality of Near-Patient Blood Cholesterol and Glucose Determinations
Clin. Chem., August 1, 2000; 46(8): 1085 - 1090.
[Abstract] [Full Text] [PDF]


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Copyright © 1987 by the American Association for Clinical Chemistry.