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Clinical Chemistry 33: 62-66, 1987;
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Clinical Chemistry, Vol 33, 62-66, Copyright © 1987 by American Association for Clinical Chemistry

Determination of neopterin in serum and urine

ER Werner, A Bichler, G Daxenbichler, D Fuchs, LC Fuith, A Hausen, H Hetzel, G Reibnegger and H Wachter

Concentrations of neopterin, a product of activated macrophages, in serum from 662 apparently healthy individuals (ages 1 to 97 years, median 22 years) were measured by radioimmunoassay and the results statistically analyzed. Consistent with prior investigations on the urinary excretion of neopterin, we found no significant sex dependence, but values for subjects younger than 18 or older than 75 years were significantly higher. Renal clearance of neopterin in nine healthy individuals was 218 (SD 44) mL/min, which suggests that the kidneys have an active role in neopterin excretion. Results for neopterin concentrations measured in serum by RIA and "high-performance" liquid chromatography (HPLC) are consistent, but for urinary neopterin the concordance between methods was weak. Therefore, the RIA should be used only for measuring neopterin in serum. In comparison of the clinical utility of serum neopterin and urinary neopterin/creatinine concentrations, in patients with gynecological tumors, the latter values (measured by HPLC) discriminated slightly better between patients with favorable and unfavorable prognoses.


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Copyright © 1987 by the American Association for Clinical Chemistry.