Clinical Chemistry
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Clinical Chemistry 33: 1771-1773, 1987;
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Clinical Chemistry, Vol 33, 1771-1773, Copyright © 1987 by American Association for Clinical Chemistry

Use of immunoglobulin heavy- and light-chain measurements compared with existing techniques as a means of typing monoclonal immunoglobulins

JT Whicher, M Wallage and R Fifield
Department of Chemical Pathology, Bristol Royal Infirmary, U.K.

Using automated measurements of kappa and lambda light chains and IgG, IgA, and IgM, we assessed the utility of the kappa/lambda ratio and the heavy chain/light chain ratio in characterizing monoclonal immunoglobulins previously identified by sensitive electrophoresis on agarose gel and typed by immunofixation or immunoelectrophoresis. We examined 348 selected samples, of which 165 contained monoclonal components, finding that 93.4% were detected and 89% correctly typed by this approach. Eight samples were shown to contain monoclonal light chains that were not visible as bands on electrophoresis but demonstrated abnormalities of the kappa/lambda or heavy chain/light chain ratio.


The following articles in journals at HighWire Press have cited this article:


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 Clin. Chem.Home page
M. Attaelmannan and S. S. Levinson
Understanding and Identifying Monoclonal Gammopathies
Clin. Chem., August 1, 2000; 46(8): 1230 - 1238.
[Abstract] [Full Text] [PDF]


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Copyright © 1987 by the American Association for Clinical Chemistry.