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Clinical Chemistry 33: 1837-1840, 1987;
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Clinical Chemistry, Vol 33, 1837-1840, Copyright © 1987 by American Association for Clinical Chemistry

A latex agglutination assay for D dimer: evaluation and application to the diagnosis of thrombotic disease

CJ Hillyard, AS Blake, K Wilson, DB Rylatt, S Miles, R Bunch, MJ Elms, A Barnes and PG Bundesen
Centre for Applied Immunology, Queensland Institute of Technology, Brisbane, Australia.

Although latex agglutination assays have been used for some years to diagnose thrombotic disorders, only recently has it been possible to measure specifically the products of fibrin breakdown in the presence of fibrinogen degradation products, by using monoclonal antibodies. We have evaluated a preparation of latex particles coupled to the monoclonal antibody DD-3B6/22, which is specific for cross-linked fibrin degradation products (XDP) and allows accurate discrimination between normal and pathological conditions. Of samples from 515 apparently healthy volunteers, 97.7% failed to agglutinate the latex; the normal reference interval for XDP determined by enzyme immunoassay was less than 78-320 micrograms/L. The use of different anticoagulants with or without the addition of a protease inhibitor had no significant effects on the results of the latex assay. The latex preparation provides a useful, rapid diagnostic tool for assaying small numbers of samples or as an emergency test.


The following articles in journals at HighWire Press have cited this article:


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 Arch Intern MedHome page
I. Kutinsky, S. Blakley, and V. Roche
Normal D-Dimer Levels in Patients With Pulmonary Embolism
Arch Intern Med, July 26, 1999; 159(14): 1569 - 1572.
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Copyright © 1987 by the American Association for Clinical Chemistry.