Clinical Chemistry
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Clinical Chemistry 33: 1863-1868, 1987;
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Clinical Chemistry, Vol 33, 1863-1868, Copyright © 1987 by American Association for Clinical Chemistry

Determination, by radioimmunoassay, of the mass of lactate dehydrogenase isoenzyme 1 in human serum and of its rate of removal from serum after a myocardial infarction

DA Smith, FY Leung, G Jablonsky and AR Henderson
Department of Clinical Biochemistry, University Hospital (University of Western Ontario), London, Canada.

In this radioimmunoassay of lactate dehydrogenase-1 (LD-1; EC 1.1.1.27) in human serum we use a commercial LD-1-selective assay system and a goat antiserum. We have determined the fractional rate of disappearance from serum and the half-life of LD-1, in terms of both enzyme activity and enzyme mass, in 21 myocardial infarction patients. Our evidence suggests that this isoenzyme is inactivated in serum. Furthermore, our data suggest that the conventionally accepted half-life of about 110 h for serum LD-1 activity may grossly overestimate the actual LD-1 half- life in many post-myocardial infarction patients.




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Copyright © 1987 by the American Association for Clinical Chemistry.