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Clinical Chemistry 33: 2074-2078, 1987;
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Clinical Chemistry, Vol 33, 2074-2078, Copyright © 1987 by American Association for Clinical Chemistry

Four methods compared for measuring des-carboxy-prothrombin (PIVKA-II)

J Widdershoven, P van Munster, R De Abreu, H Bosman, T van Lith, M van der Putten-van Meyel, K Motohara and I Matsuda
Laboratory of the Department of Pediatrics and Surgery, Nijmegen University Hospital, The Netherlands.

PIVKA-II (Protein Induced by Vitamin K Absence) is abnormal des- carboxylated prothrombin, which is present in vitamin K deficiency or in patients using warfarin. With a sensitive method for PIVKA-II, biochemical vitamin K deficiency can be established before clinical symptoms occur. We give an overview of methods used to detect PIVKA-II, and four selected methods are inter-compared: (a) measuring total factor II including PIVKA-II by using Echis carinatus snake venom as an activator of prothrombin; (b) measuring PIVKA-II by using snake venom as an activator of factor II after adsorption of functional factor II onto barium sulfate; (c) electrophoresis-immunofixation method; and (d) enzyme immunoassay. We found d to be the most sensitive and reliable method for PIVKA-II.


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Copyright © 1987 by the American Association for Clinical Chemistry.