Clinical Chemistry
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Clinical Chemistry 33: 2081-2082, 1987;
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Clinical Chemistry, Vol 33, 2081-2082, Copyright © 1987 by American Association for Clinical Chemistry

Antimony accumulation in hair during treatment of leishmaniasis

JG Dorea, JM Costa, J Holzbecher, DE Ryan and PD Marsden
Division of Tropical Medicine and Nutrition, Universidade de Brasilia, DF.

We used instrumental neutron activation analysis (INAA) to determine antimony in small quantities of hair from individuals living in an area of endemic leishmaniasis. The groups studied were 12 patients undergoing treatment with N-methylglucamine antimoniate, 34 patients who had received such treatment a year ago, and 17 control subjects (untreated) who were living in the same area. Patients receiving treatment showed mean and median (12.13, 2.9 micrograms/g) values for antimony in hair that significantly exceeded those in either controls (1.01, 0.4 microgram/g) or patients one year after treatment (1.54, 1.0 microgram/g). We conclude that INAA can be useful in monitoring and differentiating such exposure to antimony in patients under treatment.




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Copyright © 1987 by the American Association for Clinical Chemistry.