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Clinical Chemistry 33: 2111-2113, 1987;
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Clinical Chemistry, Vol 33, 2111-2113, Copyright © 1987 by American Association for Clinical Chemistry

Increased serum lactate dehydrogenase isoenzyme 1 and "flipped" LD-1/LD- 2 ratio in myopathy associated with partial carnitine palmitoyltransferase deficiency

GC Moses and AR Henderson
Department of Clinical Biochemistry, University Hospital (University of Western Ontario), London, Canada.

We describe a case of a limb-girdle myopathy presenting with myoglobinuria. A partial deficiency of muscle carnitine palmitoyltransferase (EC 2.3.1.21) may also have been present. All "muscle-type" serum enzymes were markedly increased (to between 30- and 400-fold their respective upper reference limits) and creatine kinase (EC 2.7.3.2) isoenzyme 2 (CK-MB) was increased 130-fold but was still less than 2% of the total creatine kinase activity. The isoenzyme pattern of lactate dehydrogenase (EC 1.1.1.27) in serum was "anodic," with isoenzyme 1 greater than isoenzyme 2--an unusual pattern for myopathies. The possible physiological basis for such a finding is discussed.




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Copyright © 1987 by the American Association for Clinical Chemistry.