Clinical Chemistry
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Clinical Chemistry 33: 227-236, 1987;
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Clinical Chemistry, Vol 33, 227-236, Copyright © 1987 by American Association for Clinical Chemistry

Noninvasive evaluation of mineral content of bone without use of ionizing radiation

CE Brown, JR Allaway, KL Brown and JH Battocletti

The mineral content of bone can be quantified by recording a 31P NMR spectrum while the bone is stationary. The quantity of mineral in the bone is determined from the spectrum with a reference standard by comparison of relative peak areas. The phosphate of bone mineral is readily distinguished from inorganic phosphate and phosphorylated metabolites dissolved in cytosol and from the head groups of phospholipids in membranes. The technical feasibility of constructing a cost-effective instrument for analysis of bone mineral content in the extremities is demonstrated. The possible utility of such a noninvasive assay for detecting osteoporosis and for monitoring the progress of treatment is discussed.


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Copyright © 1987 by the American Association for Clinical Chemistry.