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Clinical Chemistry 33: 566-569, 1987;
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Clinical Chemistry, Vol 33, 566-569, Copyright © 1987 by American Association for Clinical Chemistry

Clinical value of immunoradiometric assay of thyrotropin for patients with nonthyroidal illness and taking various drugs

R John, PE Evans, MF Scanlon and R Hall

Using a two-site immunoradiometric assay, we measured concentrations of thyrotropin (TSH) in serum of 134 clinically euthyroid subjects, 93 patients with nonthyroidal illness, and 80 patients who were being treated with various drugs. Abnormal concentrations of TSH, free thyroxin, and free triiodothyronine, respectively, were recorded in serum of three (3.2%), 19 (20.4%), and 37 (39.8%) of the patients with nonthyroidal illness and in three (3.8%), five (6.3%), and 10 (12.5%) of the patients taking drugs. TSH could be detected in all patients' serum samples. We conclude that, for most patients without thyroid disease, a basal (i.e., unstimulated) measurement of their TSH concentration in serum will indicate their thyroid status more reliably than will assay of free thyroxin or free triiodothyronine.


The following articles in journals at HighWire Press have cited this article:


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 Arch Intern MedHome page
C. T. Sawin, A. Geller, M. M. Kaplan, P. Bacharach, P. W. F. Wilson, and J. M. Hershman
Low Serum Thyrotropin (Thyroid-Stimulating Hormone) in Older Persons Without Hyperthyroidism
Arch Intern Med, January 1, 1991; 151(1): 165 - 168.
[Abstract] [PDF]

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 ANN INTERN MEDHome page
M. Helfand and L. M. Crapo
Monitoring Therapy in Patients Taking Levothyroxine
Ann Intern Med, September 15, 1990; 113(6): 450 - 454.
[Abstract] [PDF]

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 Asia Pac J Public HealthHome page
A. Ouyang, T. Su, X. Pang, and J. M. Hershman
Serum TSH, FT3, and FT4 Levels in Inhabitants of an Endemic Goiter Area in China Supplied Iodized Salt for Twenty-five Years
Asia Pac J Public Health, October 1, 1989; 3(4): 301 - 305.
[Abstract] [PDF]


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Copyright © 1987 by the American Association for Clinical Chemistry.