Clinical Chemistry
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Clinical Chemistry 33: 569-571, 1987;
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Clinical Chemistry, Vol 33, 569-571, Copyright © 1987 by American Association for Clinical Chemistry

Ascorbic acid as an antioxidant in measurements of catecholamines in plasma

D Hugh, A Grennan, MA Abugila and C Weinkove

Sodium metabisulfite, commonly used to prevent the oxidation of catecholamines during extraction from plasma onto alkaline alumina, does not prevent their subsequent degradation in acetic acid eluates. However, ascorbic acid, a potent antioxidant, is extracted with the catecholamines onto the alumina and prevents such destruction. However, ascorbic acid may interfere with the electrochemical measurement of catecholamines, unless sequential oxidation and reduction are used. Other methods of minimizing catecholamine oxidation in acetic acid eluates include refrigerating at 4 degrees C and capping the sample vials to exclude atmospheric oxygen.


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 J. Exp. Biol.Home page
N. Whiteley and S Egginton
Antarctic fishes have a limited capacity for catecholamine synthesis
J. Exp. Biol., January 12, 1999; 202(24): 3623 - 3629.
[Abstract] [PDF]


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Copyright © 1987 by the American Association for Clinical Chemistry.