Clinical Chemistry
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Clinical Chemistry 33: 1133-1136, 1987;
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Clinical Chemistry, Vol 33, 1133-1136, Copyright © 1987 by American Association for Clinical Chemistry

Intra-individual variation of analytes in serum from patients with chronic liver diseases

WG Holzel

The average biological intra-individual CV in 20 patients with chronic liver diseases (CLD), estimated for 14 analytes during a stationary phase, significantly exceeded that for a normal group in the cases of Na+, K+, Cl-, total protein, albumin, cholinesterase, hemoglobin, and alpha-amylase; it did not differ significantly from the normal group for cholesterol, alkaline phosphatase, aspartate aminotransferase, and alanine aminopeptidase; and it was significantly lower than in the normal group for alanine aminotransferase and gamma- glutamyltransferase. There were no significant sex-related differences in mean intra-individual variation in CLD patients. Individual values were gaussian-distributed for all analytes, including enzymes. The estimated biological component of intra-individual variation and the analytical variation as determined for each laboratory can be used to derive decision-making criteria in monitoring CLD.


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D. R. Dufour, J. A. Lott, F. S. Nolte, D. R. Gretch, R. S. Koff, and L. B. Seeff
Diagnosis and Monitoring of Hepatic Injury. I. Performance Characteristics of Laboratory Tests
Clin. Chem., December 1, 2000; 46(12): 2027 - 2049.
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Copyright © 1987 by the American Association for Clinical Chemistry.