Clinical Chemistry
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Clinical Chemistry 33: 1170-1176, 1987;
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Clinical Chemistry, Vol 33, 1170-1176, Copyright © 1987 by American Association for Clinical Chemistry

Using the coefficient of correlation in method-comparison studies

MJ Bookbinder and KJ Panosian

The coefficient of correlation (R) is one of the most commonly computed statistics in method-comparison studies. Usually, it is simply quoted without interpretation. In this paper, we show how R may be used to detect interference, nonlinearity, and misuse of the imprecision components. Specifically, one may precisely predict what R should be by considering the imprecisions of the two methods being compared, even before the comparison is performed. When the actual R disagrees with the predicted R, then one of the mentioned effects is present. We also describe a statistical test to detect these effects at the P = 0.05 level, then evaluate this test by using computer simulation and present two examples of its use. We also present the theory underlying the usage of R, including how R is affected by the distribution and range of the data, by the joint imprecisions of the methods being compared, by the sample size, and by the randomness of the specimen-selection process.


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Copyright © 1987 by the American Association for Clinical Chemistry.