Clinical Chemistry
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Clinical Chemistry 33: 1237-1241, 1987;
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Clinical Chemistry, Vol 33, 1237-1241, Copyright © 1987 by American Association for Clinical Chemistry

Clinical significance of a low concentration of thyrotropin: five immunometric "kit" assays compared

ML Piketty, JN Talbot, S Askienazy and G Milhaud

We compared results of five sensitive immunometric assays of serum thyrotropin (TSH) in controls and in different groups of patients with hyperthyroidism, untreated or treated; secondary hypothyroidism; nonthyroidal illness (NTI); or depression; or who were being treated with amiodarone. With most kits, measured TSH concentrations did not overlap between controls and hyperthyroid patients. In untreated secondary hypothyroidism TSH was not always undetectable. Patients with NTI and depression showed many low TSH values, and among these categories of patients, we observed large discrepancies among the kits. This lack of specificity at low concentration means that one cannot assess hyperthyroidism by TSH measurement alone, but it can be used as the first screening test. Similarly, TSH determination cannot be used alone in monitoring therapy (e.g., with carbimazole, thyroxin, amiodarone) to assess the presence of hyperthyroidism. Nonetheless, this assay plays a well-established role in hypothyroidism detection. Four of the five kits were found useful for clinical evaluation, the fifth less so.


The following articles in journals at HighWire Press have cited this article:


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 Arch Intern MedHome page
G. Sundbeck, R. Jagenburg, P.-M. Johansson, S. Eden, and G. Lindstedt
Clinical Significance of Low Serum Thyrotropin Concentration by Chemiluminometric Assay in 85-Year-Old Women and Men
Arch Intern Med, March 1, 1991; 151(3): 549 - 556.
[Abstract] [PDF]

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 Arch Intern MedHome page
D. A. Ehrmann, M. Weinberg, and D. H. Same
Limitations to the Use of a Sensitive Assay for Serum Thyrotropin in the Assessment of Thyroid Status
Arch Intern Med, February 1, 1989; 149(2): 369 - 372.
[Abstract] [PDF]

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 ANN INTERN MEDHome page
D. A. Ehrmann and D. H. Sarne
Serum Thyrotropin and the Assessment of Thyroid Status
Ann Intern Med, February 1, 1989; 110(3): 179 - 181.
[Abstract] [PDF]


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Copyright © 1987 by the American Association for Clinical Chemistry.