Clinical Chemistry
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Clinical Chemistry 33: 1436-1438, 1987;
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Clinical Chemistry, Vol 33, 1436-1438, Copyright © 1987 by American Association for Clinical Chemistry

Deciding the optimum interval between specimen collections: theory and nomograms

CG Fraser and MC Browning

The time interval between collection of specimens from an individual patient is usually determined empirically. For analytes whose values decline according to first-order kinetics--for example, enzyme activities in serum after an acute myocardial infarction, tumor markers in serum after excision of the tumor, and drugs in serum after an overdose--the minimum time between collections (delta T) depends on the elimination half-life (t) and the analytical precision (CVA), according to the equation: delta T = (1/log2) X t X log (2.33 CVA/100 + 1). Nomograms showing this relationship graphically have been generated.




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Copyright © 1987 by the American Association for Clinical Chemistry.