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Clinical Chemistry 34: 2044-2047, 1988;
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Clinical Chemistry, Vol 34, 2044-2047, Copyright © 1988 by American Association for Clinical Chemistry

23Na nuclear magnetic resonance study of Na+-K+ pump inhibition by a fraction from uremic toxins [published erratum appears in Clin Chem 1989 Apr;35(4):670]

P Gallice, JP Monti, M Baz, A Murisasco and A Crevat
Laboratoire de Biophysique, Faculte de Pharmacie, Marseille, France.

An in vitro inhibitor of Na+/K+-transporting ATPase (EC 3.6.1.37) was isolated from uremic plasma and normal urine by liquid chromatography. A 23Na nuclear magnetic resonance study involving living erythrocytes showed that this inhibitor causes impairment of the Na+-K+ pump of intact erythrocytes. This finding may explain the high intra- erythrocytic sodium concentration in those uremic patients exhibiting a high concentration of this inhibitor. The presence of this same inhibitor in normal urine suggests that it may play a physiological role.




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Copyright © 1988 by the American Association for Clinical Chemistry.