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Clinical Chemistry 34: 2092-2095, 1988;
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Clinical Chemistry, Vol 34, 2092-2095, Copyright © 1988 by American Association for Clinical Chemistry

Age-related reference values for free amino acids in first morning urine specimens

PR Parvy, JI Bardet, DM Rabier and PP Kamoun
Laboratoire de Biochimie Medicale B, Hopital Necker-Enfants Malades, Paris, France.

We determined age-related reference values for urinary free amino acids (in mmol/mol creatinine) in first morning urine specimens from 360 control subjects who were divided into nine age groups: birth to 1 month, 1-6 months, 6-12 months, 1-2 years, 2-4 years, 4-7 years, 7-10 years, 10-13 years, and older than 13 years. Except for taurine and 3- methylhistidine, the concentration of all the amino acids decreased with increasing age. The use of these results to detect aminoacidopathies and tubulopathies is discussed.


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U. F.H. Engelke, M. L.F. Liebrand-van Sambeek, J. G.N. de Jong, J. G. Leroy, E. Morava, J. A.M. Smeitink, and R. A. Wevers
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R. Venta
Year-Long Validation Study and Reference Values for Urinary Amino Acids Using a Reversed-Phase HPLC Method
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