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Clinical Chemistry 34: 2148-2150, 1988;
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Clinical Chemistry, Vol 34, 2148-2150, Copyright © 1988 by American Association for Clinical Chemistry

Measurement of parathyrin in blood from thyroid veins: two radioimmunoassays compared in patients with primary hyperparathyroidism [published erratum appears in Clin Chem 1988 Nov;34(11):2370]

M Munoz-Torres, J Diaz, F Escobar-Jimenez, G Gonzalez-Calvin, C Vara, ME Ruiz Requena, R Vara and I Morales
Department of Medicine, (Endocrinology Division), University Hospital, Granada, Spain.

We measured parathyrin (PTH) in peripheral venous blood samples and in thyroid veins (both homolateral and contralateral to the lesion) in 13 patients with surgically confirmed parathyroid adenomas. Two different RIAs were used, one specific to the mid-region of the molecule (44-68, M-PTH), the other specific to the carboxy-terminal region (65-84, C- PTH). With the M-PTH assay we established a statistically significant multiple correlation (P less than 0.05) between the PTH concentrations in blood from the peripheral and thyroid veins; no significant correlation was found when we used the C-PTH assay. Our results confirm the superiority of the M-PTH RIA over the C-PTH RIA for study of hormonal secretion in primary hyperparathyroidism.




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Copyright © 1988 by the American Association for Clinical Chemistry.