Clinical Chemistry
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Clinical Chemistry 34: 2330-2332, 1988;
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Clinical Chemistry, Vol 34, 2330-2332, Copyright © 1988 by American Association for Clinical Chemistry

Liquid-chromatographic determination of fleroxacin in serum and urine

WM Awni, JA Maloney and KL Heim-Duthoy
College of Pharmacy, University of Minnesota, Minneapolis.

This highly sensitive, accurate, and reproducible HPLC method for determining fleroxacin in human serum and urine makes use of a common C18 column, a fluorescence detector, and an internal standard. Serum samples require a simple extraction procedure; urine must be diluted. The method, which we have used extensively for pharmacokinetic assessment of fleroxacin in patients, measures concentrations as low as 5 micrograms/L.




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Copyright © 1988 by the American Association for Clinical Chemistry.