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Clinical Chemistry 34: 2382-2384, 1988;
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Clinical Chemistry, Vol 34, 2382-2384, Copyright © 1988 by American Association for Clinical Chemistry

Serum lipoperoxidation products in an infant with hemolytic-uremic syndrome

RE Brown, SL Alade, JA Knight and BJ Evans
Department of Pathology, Cook-Fort Worth Children's Medical Center, TX 76104.

We detected increased concentrations of lipoperoxidation products, as malondialdehyde, in the serum of an infant with classic hemolytic- uremic syndrome. The concentrations declined when peritoneal dialysis was initiated and eventually returned to normal after clinical recovery. Our observation adds to the existing body of evidence that links the pathogenesis of hemolytic-uremic syndrome to peroxidative damage and to the rationale for using antioxidant agents as part of the therapy for this disease process.





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