Clinical Chemistry
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Clinical Chemistry 34: 2415-2417, 1988;
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Clinical Chemistry, Vol 34, 2415-2417, Copyright © 1988 by American Association for Clinical Chemistry

Neopterin estimation compared with the ratio of T-cell subpopulations in persons infected with human immunodeficiency virus-1

D Fuchs, M Banekovich, A Hausen, J Hutterer, G Reibnegger, ER Werner, FD Gschnait, MP Dierich and H Wachter
Institute of Medical Chemistry and Biochemistry, University of Innsbruck, Austria.

We measured neopterin, a biochemical indicator for the activation of cell-mediated immune reactions, in urines from 105 individuals at risk of infection with human immunodeficiency virus-1 (HIV-1), 83 of whom were seropositive for antibody to HIV-1. We compared absolute numbers of T-cell subsets (CD4+ helper/inducer T-cells, CD8+ suppressor/cytotoxic T-cells), and the ratio of CD4+ T-cells to CD8+ T- cells with the urinary neopterin concentrations. Concentrations of neopterin in urine were inversely correlated with absolute numbers of CD4+ T-cells and with CD4+/CD8+ ratios in anti-HIV-1 seropositive subjects but not in those seronegative. Various statistical comparisons of the data further demonstrated that neopterin concentrations showed larger differences between anti-HIV-1 seronegative and seropositive subjects than absolute numbers of CD4+ T-cells or CD4+/CD8+ ratios. These results seem to indicate that neopterin concentrations increase earlier in the course of HIV-1 infection, before effects on T-cell subpopulations are detectable, and may further support the suggestion that neopterin measurement could be of use for monitoring infected subjects or predicting the progression of disease.


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 Arch Intern MedHome page
E. D. Gorham, F. C. Garland, D. L. Mayers, R. R. Goforth, S. K. Brodine, P. J. Weiss, M. S. McNally, and Navy Retroviral Working Group
CD4 Lymphocyte Counts Within 24 Months of Human Immunodeficiency Virus Seroconversion: Findings in the US Navy and Marine Corps
Arch Intern Med, April 12, 1993; 153(7): 869 - 876.
[Abstract] [PDF]


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Copyright © 1988 by the American Association for Clinical Chemistry.