Clinical Chemistry
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Clinical Chemistry 34: 2545-2546, 1988;
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Clinical Chemistry, Vol 34, 2545-2546, Copyright © 1988 by American Association for Clinical Chemistry

Stability of serum fructosamine during storage

P Koskinen and K Irjala
Central Laboratory, University Central Hospital of Turku, Finland.

Stability of serum fructosamine during storage was evaluated in serum specimens obtained from 27 diabetic individuals. The samples were divided into six aliquots, which were stored at -20 degrees C and -70 degrees C for two, eight, and 16 months. The minor systematic differences between the six treatments contrasted with the considerable variation of individual specimens. The mean percentage changes in the six treatments ranged between -4.6% and 7.5%, whereas the changes in individual specimens ranged from -20% to 26.7%. Several factors evidently contribute to this variation, one being progressive in vitro glycation, especially at -20 degrees C. Small changes in fructosamine concentrations between consecutively drawn specimens, determined after storage, evidently should be interpreted cautiously. Low temperatures, at least -70 degrees C, are preferable to minimize pre-analytical variation during storage.


The following articles in journals at HighWire Press have cited this article:


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 J. Am. Coll. Nutr.Home page
G. Misciagna, G. De Michele, A. M. Cisternino, V. Guerra, G. Logroscino, and J. L. Freudenheim
Dietary Carbohydrates and Glycated Proteins in the Blood in Non Diabetic Subjects
J. Am. Coll. Nutr., February 1, 2005; 24(1): 22 - 29.
[Abstract] [Full Text] [PDF]


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Copyright © 1988 by the American Association for Clinical Chemistry.