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Clinical Chemistry 34: 407-410, 1988;
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Clinical Chemistry, Vol 34, 407-410, Copyright © 1988 by American Association for Clinical Chemistry

Intact parathyrin in postmenopausal women

LJ Sokoll, FD Morrow, DM Quirbach and B Dawson-Hughes
Calcium and Bone Metabolism Laboratory, USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111.

To establish a reference range, we measured intact parathyrin (parathyroid hormone, PTH) in 245 healthy postmenopausal women, ages 42- 75 years, with use of the Allegro Intact PTH Kit from Nichols Institute Diagnostics. We also assayed serum from a subset of 120 of the women with kits specific for mid-molecule PTH. The mean intact PTH concentration for the 245 women was 32 ng/L (95% confidence interval 14- 60 ng/L). Intact PTH values in these subjects were not normally distributed, although calcium concentrations in the same samples were. There was positive, but not significant (r = 0.12, P = 0.06), correlation between intact PTH and age, and a significant negative correlation between serum calcium and intact PTH that was not observed between calcium and mid-molecule PTH. The improved sensitivity of the intact PTH assay makes it useful in studies of calcium homeostasis in the normal population.


The following articles in journals at HighWire Press have cited this article:


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 J. Clin. Endocrinol. Metab.Home page
J.-C. Souberbielle, C. Cormier, C. Kindermans, P. Gao, T. Cantor, F. Forette, and E. E. Baulieu
Vitamin D Status and Redefining Serum Parathyroid Hormone Reference Range in the Elderly
J. Clin. Endocrinol. Metab., July 1, 2001; 86(7): 3086 - 3090.
[Abstract] [Full Text] [PDF]


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