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Clinical Chemistry, Vol 34, 439-443, Copyright © 1988 by American Association for Clinical Chemistry
F Pontet, X Gue, C Dosquet, J Caen and F Rousselet
Laboratorie Central de Biochimie, Hopital Lariboisiere, Paris, France.
We noted the following major immunochemical changes in the final course of a gamma heavy-chain disease associated with a myelomonocytic leukemia: an important oligoclonal increase of IgG1/kappa, during sepsis development, whereas the lambda molecules decreased and IgG2 and IgG3 completely disappeared in a one-month interval. Initial concentrations of IgG4 were stable during that period, and gamma 1 heavy chains were slightly increased. This is a very unusual observation of the successive immunochemical events terminating a gamma heavy-chain disease.
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