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Clinical Chemistry 34: 568-575, 1988;
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Clinical Chemistry, Vol 34, 568-575, Copyright © 1988 by American Association for Clinical Chemistry

Thyrotroph function assessed by sensitive measurement of thyrotropin with three immunoradiometric assay kits: analytical evaluation and comparison with the thyroliberin stimulation test

FH Wians Jr, JM Jacobson, J Dev, JI Heald and G Ortiz
Department of Pathology/SGHQLCC, Wilford Hall USAF Medical Center, Lackland AFB, San Antonio, TX 78236-5300.

We evaluated the analytical and clinical performance of three "sensitive" immunoradiometric assay (IRMA) kits (Tandem-R TSH HS, Hybritech, Inc.; EchoClonal TSH, Bio-Rad; Coat-A-Count TSH IRMA, Diagnostic Products Corp.) for measurement of thyrotropin (TSH) and compared their performance against a "regular" IRMA (ARIA-HT, Becton- Dickinson) to determine whether these assays might eliminate the need to perform the thyroliberin (TRF) stimulation test. We concluded that the Tandem and EchoClonal kits may obviate the need to perform TRF stimulation tests in some patients. Using only the basal TSH concentration to predict the TSH response to TRF, we found all three sensitive TSH assays to be useful for detecting abnormal thyrotroph function. Dose-response, linearity, analytical recovery, and specificity were acceptable for all kits, but intra-assay precision at very low TSH concentrations and analytical sensitivity differed considerably among the kits. Using the EchoClonal assay, we established a normal reference interval for TSH of 0.4-4.6 milli-int. units/L.


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[Abstract] [Full Text] [PDF]


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Copyright © 1988 by the American Association for Clinical Chemistry.