Clinical Chemistry
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Clinical Chemistry 34: 665-667, 1988;
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Clinical Chemistry, Vol 34, 665-667, Copyright © 1988 by American Association for Clinical Chemistry

Cerebrospinal fluid IgG and IgM indexes as indicators of active neurosyphilis

EA Hische, JA Tutuarima, EC Wolters, L van Trotsenburg, RV van Eyk, JD Bos, A Albert and HJ van der Helm
Department of Clinical Chemistry, Academic Hospital, University of Amsterdam, The Netherlands.

Serological and non-serological tests were performed in matched samples of cerebrospinal fluid and serum from 236 syphilitic patients. An increased IgG or IgM index, or both, was found about 70 times more often in symptomatic neurosyphilis than in latent syphilis without involvement of the central nervous system. An increased Ig index, together with a cell count greater than 5/microL, was only found in symptomatic neurosyphilis. Although the numbers of data are small, we conclude that the IgG and IgM indexes are valuable tests in the diagnosis of syphilitic involvement of the central nervous system.




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Copyright © 1988 by the American Association for Clinical Chemistry.