Clinical Chemistry
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Clinical Chemistry 34: 685-690, 1988;
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Clinical Chemistry, Vol 34, 685-690, Copyright © 1988 by American Association for Clinical Chemistry

Total, tartrate-resistant, and tartrate-inhibited acid phosphatases in serum: biological variations and reference limits

F Schiele, Y Artur, AY Floc'h and G Siest
Centre de Medecine Preventive, Vandoeuvre-les-Nancy, France.

We studied several factors affecting biological variation in serum acid phosphatases in a population of 1195 apparently healthy subjects four years old or older. We assayed total acid phosphatase activities in the presence of a transphosphorylating agent and using alpha-naphthyl phosphate as substrate. The main factors modifying total and tartrate- resistant acid phosphatases activities in serum are similar to those observed for total and bone alkaline phosphatases activities: age, sex, and hormonal state (puberty or menopause). The tartrate-inhibited acid phosphatase activity is, however, independent of biological variations. Finally, we propose reference limits for total, tartrate-resistant, and tartrate-inhibited acid phosphatases in serum.


The following articles in journals at HighWire Press have cited this article:


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 Clin. Chem.Home page
M. Nakanishi, K. Yoh, K. Uchida, S. Maruo, and A. Matsuoka
Improved method for measuring tartrate-resistant acid phosphatase activity in serum
Clin. Chem., February 1, 1998; 44(2): 221 - 225.
[Abstract] [Full Text] [PDF]


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Copyright © 1988 by the American Association for Clinical Chemistry.