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Clinical Chemistry 34: 973-975, 1988;
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Clinical Chemistry, Vol 34, 973-975, Copyright © 1988 by American Association for Clinical Chemistry

Identification of HIV-specific oligoclonal immunoglobulins in serum of carriers of HIV antibody

NM Papadopoulos, R Costello, M Ceroni and HM Moutsopoulos
Clinical Chemistry Service, Clinical Center, NINCDS, Bethesda, MD 20892.

Zone electrophoresis on agarose gel was performed on serum samples from HIV-antibody carriers and negative controls. Nitrocellulose strips precoated with an HIV preparation were then placed on top of the gels and developed by an immunoblotting procedure. A positive reaction was demonstrated between the HIV antigens and the HIV-antibody-positive serum samples with hypergammaglobulinemia and oligoclonal IgG bands. A negative reaction was found between the HIV antigens and HIV-antibody- negative serum samples from a normal person and a patient with monoclonal gammopathy. The presence of oligoclonal IgG bands in the serum of HIV-antibody carriers, and their positive identification with HIV antigens, indicates a specific immune response of the host to the HIV infection and supports the use of oligoclonal IgG bands as markers to follow the course of HIV infection.


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Copyright © 1988 by the American Association for Clinical Chemistry.