Clinical Chemistry
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Clinical Chemistry 34: 975-977, 1988;
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Clinical Chemistry, Vol 34, 975-977, Copyright © 1988 by American Association for Clinical Chemistry

Interference of fetal hemoglobin with the spectrophotometric measurement of carboxyhemoglobin

HJ Vreman, RB Ronquillo, RL Ariagno, HC Schwartz and DK Stevenson
Department of Pediatrics, Stanford University School of Medicine, CA 94305-5119.

We measured the concentration of carboxyhemoglobin (HbCO) in blood samples from 32 neonates by spectrophotometry (IL282 CO-Oximeter) and gas chromatography, finding a strong positive correlation (r = 0.89) between the concentration of fetal hemoglobin (Hb F) and HbCO as measured by spectrophotometry, but not by gas chromatography. Thus, Hb F interferes with the determination of HbCO by spectrophotometric techniques by falsely increasing apparent HbCO in direct proportion to Hb F. We conclude that, when Hb F is known or suspected to be present, blood HbCO cannot be reliably determined by methods based on spectrophotometry.


The following articles in journals at HighWire Press have cited this article:


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 Arch Pediatr Adolesc MedHome page
H. C. Lu, R. D. Shih, S. Marcus, B. Ruck, and T. Jennis
Pseudomethemoglobinemia: A Case Report and Review of Sulfhemoglobinemia
Arch Pediatr Adolesc Med, August 1, 1998; 152(8): 803 - 805.
[Abstract] [Full Text] [PDF]

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 CLIN PEDIATRHome page
D. K. Stevenson
The Carboxyhemoglobin Method for Estimating Bilirubin Production in Neonates: Japanese Studies
Clinical Pediatrics, December 1, 1992; 31(12): 708 - 711.
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