Clinical Chemistry
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Clinical Chemistry 34: 1036-1040, 1988;
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Clinical Chemistry, Vol 34, 1036-1040, Copyright © 1988 by American Association for Clinical Chemistry

Heterogeneity of lipoprotein Lp(a) and apolipoprotein(a)

GF Grinstead and RD Ellefson
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905.

We have purified Lp(a) lipoproteins from sera of four subjects by ultracentrifugation, selective precipitation, and chromatofocusing. Each subject had two forms of serum Lp(a) that were separable by chromatofocusing. We purified apolipoprotein (a) [apo(a)] from the eight isolated Lp(a)s and obtained only one form of apo(a) from each subject. The four apo(a)s seen on sodium dodecyl sulfate-polyacrylamide gel electrophoresis had different apparent molecular masses, ranging from 275 to 440 kDa. Chemical deglycosylation of the smallest apo(a) yielded a 235 kDa protein, which may be a core protein structure common to all apo(a)s. We conclude that there are many forms of serum Lp(a) and apo(a). The heterogeneity of serum Lp(a) particles can be ascribed in part to differences in size of apo(a), but other factors must account for the existence within a single patient of different Lp(a)s that contain apparently identical apo(a). One must consider the heterogeneity of Lp(a) when designing assays for this lipoprotein.


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Copyright © 1988 by the American Association for Clinical Chemistry.