Clinical Chemistry
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Clinical Chemistry 34: 1110-1114, 1988;
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Clinical Chemistry, Vol 34, 1110-1114, Copyright © 1988 by American Association for Clinical Chemistry

Evaluation of a new strategy for detection of thyroid dysfunction in the routine laboratory [published erratum appears in Clin Chem 1988 Nov;34(11):2370]

R John, R Henley, G Lloyd and GH Elder
Department of Medical Biochemistry, University Hospital of Wales, Health Park, Cardiff, U.K.

We assessed the use of a new strategy for detecting thyroid disorders, utilizing a sensitive assay for concentrations of thyrotropin (TSH) and free thyroid hormone in serum as follow-up tests. Of 1279 patients who were not on thyroxin (T4) replacement treatment, 82% could be classified as euthyroid and would require no further tests. In patients who were on T4 replacement, 41% fell into the euthyroid category and would require no further tests. Using this strategy to replace our existing strategy of free thyroxin as a "first-line" test would reduce the proportion of patients who would require one or more follow-up tests from 49% to 24%.


The following articles in journals at HighWire Press have cited this article:


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C. van Walraven and C. D. Naylor
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R. A. Nordyke, T. S. Reppun, L. D. Madanay, J. C. Woods, A. P. Goldstein, and L. A. Miyamoto
Alternative Sequences of Thyrotropin and Free Thyroxine Assays for Routine Thyroid Function Testing: Quality and Cost
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