Clinical Chemistry
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Clinical Chemistry 34: 1121-1123, 1988;
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Clinical Chemistry, Vol 34, 1121-1123, Copyright © 1988 by American Association for Clinical Chemistry

An analysis for blood manganese used to assess environmental exposure

GA Hams and JK Fabri
Department of Clinical Chemistry, The Prince of Wales Hospital, Randwick, N.S.W., Australia.

In this graphite-furnace atomic-absorption spectrometric method for measuring manganese in whole blood, we use a pyrolytic platform to minimize interference by sample matrix. For optimal sample ashing we denature the sample within the furnace with nitric acid and use oxygen as the purge gas at low temperatures. The mean manganese concentration found in blood from 15 unexposed city dwellers was 215 (2 SD 135) nmol/L. By comparison, the range of manganese concentrations in blood sampled from a group of Australian aborigines living near a surface manganese ore deposit on Groote Eylandt, Northern Territory, was much higher (median 405 nmol/L, range 175 to 990 nmol/L).




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Copyright © 1988 by the American Association for Clinical Chemistry.