Clinical Chemistry
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Clinical Chemistry 34: 1427-1430, 1988;
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Clinical Chemistry, Vol 34, 1427-1430, Copyright © 1988 by American Association for Clinical Chemistry

Rendering the "poppy-seed defense" defenseless: identification of 6- monoacetylmorphine in urine by gas chromatography/mass spectroscopy

SJ Mule and GA Casella
New York State DSAS Testing and Research Laboratory, Brooklyn 11217.

We report a sensitive, rapid, quantitative gas chromatographic/mass spectroscopic method for measuring the 6-monoacetylmorphine (6-MAM) metabolite of heroin in 0.5 mL of human urine. After a simple liquid- liquid extraction and derivatization, the trimethylsilyl derivative of 6-MAM is identified from its retention time (total ion current) and by selected ion monitoring. The limit of detection was 10 micrograms/L, corresponding to 0.2 ng of trimethylsilyl-6-MAM injected into the gas chromatograph/mass spectrometer. The presence of 6-MAM in urine is indicative of heroin. 6-MAM is not present in poppy seeds or in urine after the ingestion of products containing poppy seed.


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Copyright © 1988 by the American Association for Clinical Chemistry.