Clinical Chemistry
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Clinical Chemistry 34: 1431-1438, 1988;
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Clinical Chemistry, Vol 34, 1431-1438, Copyright © 1988 by American Association for Clinical Chemistry

In vivo 31P nuclear magnetic resonance spectroscopy of bone mineral for evaluation of osteoporosis

CE Brown, JH Battocletti, R Srinivasan, JR Allaway, J Moore and P Sigmann
Department of Biochemistry, Medical College of Wisconsin, Milwaukee 53226.

The mineral content of stationary bone samples can be quantified by 31P nuclear magnetic resonance (NMR) spectroscopy. The assay can be performed in regions of the anatomy that pose problems for absorptiometric techniques, because the mineral content is measured within a selected volume without concern for the geometry of the bone. In vivo 31P NMR spectra of the bones in human fingers and wrist are reported. Soft tissue such as marrow and skeletal muscle contributes little to the 31P NMR spectra of human fingers and wrist and thus should not seriously affect the accuracy of the mineral assay. 31P NMR spectrometry should prove helpful for confirming rapid bone mineral loss in those at risk and for monitoring response to treatment.


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Copyright © 1988 by the American Association for Clinical Chemistry.