Clinical Chemistry
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Clinical Chemistry 34: 1471-1473, 1988;
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Clinical Chemistry, Vol 34, 1471-1473, Copyright © 1988 by American Association for Clinical Chemistry

Accumulation of glycolic acid and glyoxylic acid in serum in cases of transient hyperglycinemia after transurethral surgery

C Perier, J Frey, C Auboyer, A Richard, G Aulagnier, P Heritier and A Gilloz
Laboratoire de Biochimie, Centre Hospitalier Universitaire de Saint- Etienne, Saint-Priest en Jarez, France.

Experimental data are presented here proving the accumulation of glycine in serum after transurethral prostatectomy and increased production of glycine metabolites: serine, alanine, glyoxylic acid, and glycolic acid. The presence of the metabolites glyoxylic acid and glycolic acid was demonstrated by gas-liquid chromatography and mass spectrometry. Glycine, glyoxylic acid, and glycolic acid possess neurological activity, so we examined the pathophysiology of the transurethral prostatectomy syndrome in view of the transient accumulation of these compounds in serum.


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[Abstract] [Full Text] [PDF]


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Copyright © 1988 by the American Association for Clinical Chemistry.