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Clinical Chemistry 34: 1485-1488, 1988;
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Clinical Chemistry, Vol 34, 1485-1488, Copyright © 1988 by American Association for Clinical Chemistry

Influence of hypertension and antihypertensive drugs on the biological intra-individual variation of electrolytes and lipids in serum

WG Holzel
Institute of Pathological and Clinical Biochemistry, Charite Hospital, Humboldt University, Berlin, G.D.R.

Biological intra-individual CVs for Na+, Cl-, K+, calcium, cholesterol, high-density lipoprotein cholesterol, triglycerides in serum, and hemoglobin in blood were estimated in men with essential hypertension (EH) treated with beta-blockers and diuretics, and compared with those of normotensive men. Although in EH the mean concentrations of Na+, Cl- , K+, hemoglobin, and triglycerides were increased and that of HDL cholesterol was decreased, the average intra-individual CVs did not significantly differ between the two groups. The mean concentration of cholesterol, as well as the average intra-individual CV for it, was significantly higher in EH. There was no correlation between the intra- individual CVs for the analytes and the mean blood pressure of the individuals. Individual values were normally distributed for all analytes. There was no increase of the intra-individual CV with the lapse of time between consecutively measured values. The estimated average biological intra-individual CV was used to derive decision- making criteria for interpretation of test results observed in monitoring EH.


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