Clinical Chemistry
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Clinical Chemistry 34: 1610-1613, 1988;
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Clinical Chemistry, Vol 34, 1610-1613, Copyright © 1988 by American Association for Clinical Chemistry

Amino acid concentrations in serum and aqueous humor from subjects with extreme myopia or senile cataract

JA Wuu, LY Wen, TY Chuang and GG Chang
Department of Biochemistry, National Defense Medical Center, Taipei, Taiwan, Republic of China.

With an amino acid analyzer, we measured amino acids and related compounds in serum and aqueous humor from normal Chinese and some patients with extreme myopia or senile cataracts. Forty peaks were well resolved, and their areas were used to quantify each compound. In the myopic patients, glutamate, alpha-aminoadipate, and methionine concentrations in serum were 10-fold those in the normal subjects. Values for most of the other amino acids and related compounds were also higher in myopic patients' sera. In the cataract patients, concentrations of most of these compounds were lower in serum but higher in aqueous humor than for the normal subjects. Tryptophan was present in significant amounts in sera from the normal subjects, but was not detectable in the senile-cataract patients. The ratio of amino acid concentration in aqueous humor to that in the serum (Ch/Cs) was higher in the cataract patients than in normal subjects for almost all of the compounds we measured.


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Copyright © 1988 by the American Association for Clinical Chemistry.