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Clinical Chemistry, Vol 34, 1644-1646, Copyright © 1988 by American Association for Clinical Chemistry
SJ Smith, LO Henderson, GR Cooper and WH Hannon
Division of Environmental Health Laboratory Sciences, Centers for Disease Control, Atlanta, GA 30333.
Two international apolipoprotein A-1 and B (apoA-1 and apoB) surveys were conducted in 1983 and 1986 with use of a lyophilized serum measured by 55 and 91 participants, respectively. The chief source of variability in both surveys was among laboratories, but among-method variation was significant for apoB. Comparing the 1986 with the 1983 findings, we saw a 60% decrease in apoA-1 variability among laboratories, and a similar decrease (53%) was found for apoB. Evaluation of individual measurements suggests that some collaborators may have adjusted their calibrators toward the consensus values published in 1983.
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