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Clinical Chemistry 34: 1676-1680, 1988;
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Clinical Chemistry, Vol 34, 1676-1680, Copyright © 1988 by American Association for Clinical Chemistry

Analysis of idiotypic and anti-idiotypic antibodies as models of receptor and ligand

DS Linthicum, MB Bolger, PH Kussie, GM Albright, TA Linton, S Combs and D Marchetti
Department of Pathology and Laboratory Medicine, University of Texas Health Science Center, Houston 77225.

Antibodies to small bioactive ligands and peptides may mimic the binding characteristics of the natural receptor; in turn, the anti- idiotypic antibodies generated against the binding sites of such anti- ligand antibodies may mimic some aspects of small bioactive ligands and peptides. Among the several levels of investigation of such antibody- receptor networks are (a) the quantitative structure-activity relationships of ligand binding to antibody as compared with natural receptor; (b) the molecular modeling of antibody-receptor binding sites and the genomic basis for such structures; and (c) the characteristics of the molecular mimicry exhibited by "mimetopes" on anti-idiotypic antibodies. To illustrate the analysis encountered at each of these levels, we discuss here antibody and anti-idiotypic systems that are directed to small neuroactive ligands and their receptors.




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Copyright © 1988 by the American Association for Clinical Chemistry.