Clinical Chemistry AACC Online Job Center
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Clinical Chemistry 34: 1805-1811, 1988;
This Article
Right arrow Full Text (PDF)
Right arrow Submit an electronic Letter to
the Editor about this paper
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Stephens, T. W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Stephens, T. W.

Clinical Chemistry, Vol 34, 1805-1811, Copyright © 1988 by American Association for Clinical Chemistry

Performance of two new algorithms for estimating within- and between- method carryover evaluated statistically

TW Stephens
Department of Biochemistry, Lilly Research Laboratories, Eli Lilly and Co., Lilly Corporate Center, Indianapolis, IN 46285.

Accurate and precise algorithms for estimating within-method carryover, based on the minimization of a unique "carryover sum of squares," and between-method carryover, based on a weighted Deming regression of first sample recovery vs carryover-corrected "true" recovery, are described and compared with traditional methods by use of a Monte Carlo study. In addition, I have studied the experimental parameters that influence the accuracy and precision of carryover estimation. The new algorithm for estimating within-method carryover is unbiased under most conditions, whereas the traditional algorithm is biased low under most conditions. The new algorithm is also more precise, owing to more- efficient utilization of information contained in an analytical run performed for carryover estimation. Between-method carryover in a random-access analyzer is estimated quantitatively by the second proposed algorithm and is found to be readily and precisely determinable. Use of these methods in combination to evaluate analytical interaction should allow the prediction of carryover error under most current analytical situations.




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1988 by the American Association for Clinical Chemistry.